Platelets have important hemostatic functions in repairing blood vessels upon tissue injury. Cytokines, growth factors, and metabolites stored in platelet α‐granules and dense granules are released upon platelet activation and clotting. Emerging evidence indicates that such platelet‐derived signaling factors are instrumental in guiding tissue regeneration. Here, we discuss the important roles of platelet‐secreted signaling factors in skeletal muscle regeneration. Chemokines secreted by platelets in the early phase after injury are needed to recruit neutrophils to injured muscles, and impeding this early (...) step of muscle regeneration exacerbates inflammation at later stages, compromises neo‐angiogenesis and the growth of newly formed myofibers, and reduces post‐injury muscle force production. Platelets also contribute to the recruitment of pro‐regenerative stromal cells from the adipose tissue, and the platelet releasate may also regulate the metabolism and proliferation of muscle satellite cells, which sustain myogenesis. Therefore, harnessing the signaling functions of platelets and the platelet secretome may provide new avenues for promoting skeletal muscle regeneration in health and disease. (shrink)

Chance both guides our credences and is an objective feature of the world. How and why we should conform our credences to chance depends on the underlying metaphysical account of what chance is. I use considerations of accuracy (how close your credences come to truth-values) to propose a new way of deferring to chance. The principle I endorse, called the Trust Principle, requires chance to be a good guide to the world, permits modest chances, tells us how to listen to (...) chance even when the chances are modest, and entails but is not entailed by the New Principle. As I show, a rational agent will obey this principle if and only if she expects chance to be at least as accurate as she is on every good way of measuring accuracy. Much of the discussion, and the technical results, extend beyond chance to deference to any kind of expert. Indeed, you will trust someone about a particular question just in case you expect that person to be more accurate than you are about that question. (shrink)

While stakeholder theory has traditionally considered organization’s interactions with stakeholders in terms of independent, dyadic relationships, recent scholarship has pointed to the fact that organizations exist within a complex network of intertwining relationships [e.g., Rowley, T. J.: 1997, The Academy of Management Review 22(4), 887–910]. However, further theoretical and empirical development of the interactions between stakeholders has been lacking. In this paper, we develop a framework for understanding and measuring the effects upon the organization of competing, complementary and cooperative stakeholder (...) interactions, which we refer to as stakeholder multiplicity. We draw upon three forms of fit (i.e. fit as matching, fit as moderation, and fit as gestalts; Venkatraman, N.: 1989) to develop a framework for understanding stakeholder multiplicity based upon the direction, strength, and synergies of the interacting claims. Additionally, we draw upon the theory of stakeholder identification and salience of Mitchell et al. (1997), which we argue provides a more relevant and significantly more illustrative explanation of the nature and effects of stakeholder interactions upon the organization than the network approach of Rowley (1997). Furthermore, we ground our framework through reference to three stakeholder groups (i.e. governments, customers, and employees) and the stakeholder issue of concern for the natural environment. We propose a hierarchy of the multiplicity strength of influence of these three stakeholder groups. Potential measurement and implications are discussed. (shrink)

The present study investigated how the magnitude the word blindness suggestion effect on Stroop interference depended on hypnotic suggestibility when given as an imaginative suggestion and under conditions in which hypnosis was not mentioned. Hypnotic suggestibility is shown to be a significant predictor of the magnitude of the imaginative word blindness suggestion effect under these conditions. This is therefore the first study to show a linear relationship between the imaginative word blindness suggestion effect and hypnotic suggestibility across the whole hypnotizability (...) spectrum. The results replicate previous findings showing that highs respond to the word blindness suggestion to a greater extent than lows but extend previous work by showing that the advantage for those higher on the hypnotizability spectrum occurs even in a non-hypnotic context. Negative attitudes about hypnosis may not explain the failure to observe similar effects of the word blindness suggestion in less hypnotizable individuals. (shrink)

In Plato's Lysis, Socrates' conversation with Lysis features logical fallacies and questionable premises and closes with a blatantly eristic trick. I show how the form and content of these arguments make sense if we interpret them from the perspective of Socrates' pedagogical goals. Lysis is a competitive teenager who, along with his friend Menexenus, enjoys the game of eristic disputation. Socrates recognizes Lysis' predilections, and he constructs his arguments to engage Lysis' interests and loves, while also drawing the boy into (...) thinking philosophically about the issues that the arguments raise about love, freedom, and happiness. (shrink)

We consider the questions of whether or not large language models (LLMs) have beliefs, and, if they do, how we might measure them. First, we consider whether or not we should expect LLMs to have something like beliefs in the first place. We consider some recent arguments aiming to show that LLMs cannot have beliefs. We show that these arguments are misguided. We provide a more productive framing of questions surrounding the status of beliefs in LLMs, and highlight the empirical (...) nature of the problem. With this lesson in hand, we evaluate two existing approaches for measuring the beliefs of LLMs, one due to Azaria and Mitchell (The internal state of an llm knows when its lying, 2023) and the other to Burns et al. (Discovering latent knowledge in language models without supervision, 2022). Moving from the armchair to the desk chair, we provide empirical results that show that these methods fail to generalize in very basic ways. We then argue that, even if LLMs have beliefs, these methods are unlikely to be successful for conceptual reasons. Thus, there is still no lie-detector for LLMs. We conclude by suggesting some concrete paths for future work. (shrink)

Recently, extremist ‘populist’ parties have succeeded in obtaining large enough democratic electoral mandates both to legally make substantive changes to the law and constitution and to legally eliminate avenues to challenge their control over the government. Extremists place committed liberal democrats in an awkward position as they work to legally revolutionize their constitutions and turn them into ‘illiberal democracies’. This article analyses political responses to this problem. It argues that the twin phenomena of legal revolution and illiberal democracy reveal a (...) latent tension between the constitutional commitments to democracy and liberalism, that is, the equal chance to have one’s political goals enacted into law and individual basic rights. Political extremists make the latent tension real when they use the procedures of democratic legal change to abrogate constitutional commitments to liberalism, among other things. Although the two commitments normally coexist side by side, exceptional times raise an existential dilemma for liberal democracies: is it constitutional to democratically amend liberalism out of the constitution? After analysing the moral legitimacy of both the democratic and liberal arguments, this article concludes that liberal constitutionalism is constitutive of genuine democracy. In other words, it is unconstitutional to abrogate basic liberal commitments and it is legitimate to adopt constitutional mechanisms to guarantee liberalism – even if it means constraining democracy to do so. This article then situates ‘constrained democracy’ within the liberal current as a way to conceive of and respond to this pressing problem. It concludes by discussing four constitutional mechanisms – inspired by the German Grundgesetz – to guarantee liberalism: unambiguous lexically prior commitment to liberalism, limits on negative majorities, the eternity clause and party bans. It concludes that constrained democracy is an important constitutional guarantee of liberal democracy and that the four mechanisms, among others, are essential to enact constrained democracy. (shrink)

Is a devoted Nazi or a zombie bureaucrat a greater moral and political problem? Because the dangers of immoral fanaticism are so clear, the dangers of mindless bureaucracy are easy to overlook. Yet zombie bureaucrats have contributed substantially to the greatest catastrophes of the 20th century, doing so seemingly oblivious to the monstrous qualities of their actions. Hannah Arendt’s work on thoughtlessness raises a dilemma: if Eichmann, the architect of the Nazi Final Solution, truly was a thoughtless ‘cog’, lacking in (...) intentionality, can one really hold him morally accountable for the evil qualities of his acts? This article relates Arendt’s ‘thought’ and Strawson’s and Bilgrami’s discussion of ‘reactive attitudes’ and Sartre’s concept of ‘bad faith’. To find a basis for moral accountable in seemingly thoughtless cases like Eichmann’s. Although Arendt’s Eichmann is an extreme example, finding a basis to hold him accountable is valuable because ‘little Eichmanns’ will persist as long as impersonal forces structure and depress reactive attitudes. (shrink)

What did it mean to keep a secret in early medieval England? It was a period during which the experience of secrecy was intensely bound to the belief that God knew all human secrets, yet the secrets of God remained unknowable to human beings. In Bonds of Secrecy, Benjamin A. Saltzman argues that this double-edged conception of secrecy and divinity profoundly affected the way believers acted and thought as subjects under the law, as the devout within monasteries, and as (...) readers before books. One crucial way it did so was by forming an ethical relationship between the self and the world that was fundamentally different from its modern reflex. Whereas today the bearers of secrets might be judged for the consequences of their reticence or disclosure, Saltzman observes, in the early Middle Ages a person attempting to conceal a secret was judged for believing he or she could conceal it from God. In other words, to attempt to hide from God was to become ensnared in a serious sin, but to hide from the world while deliberately and humbly submitting to God's constant observation was often a hallmark of spiritual virtue. Looking to law codes and religious architecture, hagiographies and riddles, Bonds of Secrecy shows how legal and monastic institutions harnessed the pervasive and complex belief in God's omniscience to produce an intense culture of scrutiny and a radical ethics of secrecy founded on the individual's belief that nothing could be hidden from God. According to Saltzman, this ethics of secrecy not only informed early medieval notions of mental activity and ideas about the mind but also profoundly shaped the practices of literary interpretation in ways that can inform our own contemporary approaches to reading texts from the past. (shrink)

In this paper I hope to show that Geach misunderstands the nature of Plato's argument in the Euthyphro and more importantly the reasoning behind the dialectical strategy adopted by Socrates. Furthermore I shall argue that Geach's reading of the Euthyphro engenders serious difficulties, that stand in the way of understanding the manner in which Plato construes the problem of determining the nature of, and relationship between universal and particulars, which is of great significance because it is precisely this problem, in (...) relation to piety, that is central to the Euthyphro. In the appendix I shall sketch the outline of an argument in order to justify the assumption that the theory of Forms is present in the Euthyphro. (shrink)

Evidential Decision Theory and Causal Decision Theory are the leading contenders as theories of rational action, but both face counterexamples. We present some new counterexamples, including one in which the optimal action is causally dominated. We also present a novel decision theory, Functional Decision Theory, which simultaneously solves both sets of counterexamples. Instead of considering which physical action of theirs would give rise to the best outcomes, FDT agents consider which output of their decision function would give rise to the (...) best outcome. This theory relies on a notion of subjunctive dependence, where multiple implementations of the same mathematical function are considered to have identical results for logical rather than causal reasons. Taking these subjunctive dependencies into account allows FDT agents to outperform CDT and EDT agents in, for example, the presence of accurate predictors. (shrink)

These essays collectively present new perspectives on the history of modern science in China since 1900. Fa‐ti Fan describes how science under the Republic of China after 1911 exhibited a complex local and international character that straddled both imperialism and colonialism. Danian Hu focuses on the fate of relativity in the physics community in China after 1917. Zuoyue Wang hopes that a less nationalist political atmosphere in China will stimulate more transnational studies of modern science, which will in turn reveal (...) the underlying commonalities in different national contexts. Sigrid Schmalzer compares the socialist and the capitalist contexts for science in China and reopens the sensitive question of the “mass line” during the Cultural Revolution. Grace Shen describes the tensions early Chinese scientists felt when choosing between foreign models for modern geology and their own professional identities in China. Taken together, these accounts present us with a comparative history of modern science in China that is both globally and locally informed. (shrink)

Avicenna and the Aristotelian Left is the first English rendition of Ernst Bloch's thought-provoking monograph dedicated to the thought of Ibn Sīnā, the prominent eleventh-century Persian polymath. Published in 2019 by Columbia University Press as part of the New Directions in Critical Theory series, it joins a growing list of translations that goes back to the 1966 Spanish version by Jorge Deike Robles and, more recently, to Claude Maillard's and Nicola Allesandrini's French and Italian renditions, respectively. This new English edition (...) is based on Bloch's final version of the essay--a revised version of the original 1952 text, later incorporated as an... (shrink)

Some propositions are more epistemically important than others. Further, how important a proposition is is often a contingent matter—some propositions count more in some worlds than in others. Epistemic Utility Theory cannot accommodate this fact, at least not in any standard way. For EUT to be successful, legitimate measures of epistemic utility must be proper, i.e., every probability function must assign itself maximum expected utility. Once we vary the importance of propositions across worlds, however, normal measures of epistemic utility become (...) improper. I argue there isn’t any good way out for EUT. (shrink)

Despite their ethical intentions, ethically minded consumers rarely purchase ethical products (Auger and Devinney: 2007, Journal of Business Ethics76, 361–383). This intentions–behaviour gap is important to researchers and industry, yet poorly understood (Belk et al.: 2005, Consumption, Markets and Culture8(3), 275–289). In order to push the understanding of ethical consumption forward, we draw on what is known about the intention–behaviour gap from the social psychology and consumer behaviour literatures and apply these insights to ethical consumerism. We bring together three separate (...) insights – implementation intentions (Gollwitzer: 1999, American Psychologist54(7), 493–503), actual behavioural control (ABC) (Ajzen and Madden: 1986, Journal of Experimental Social Psychology22, 453–474; Sheeran et al.: 2003, Journal of Social Psychology, 42, 393–410) and situational context (SC) (Belk: 1975, Journal of Consumer Research2, 157–164) – to construct an integrated, holistic conceptual model of the intention–behaviour gap of ethically minded consumers. This holistic conceptual model addresses significant limitations within the ethical consumerism literature, and moves the understanding of ethical consumer behaviour forward. Further, the operationalisation of this model offers insight and strategic direction for marketing managers attempting to bridge the intention–behaviour gap of the ethically minded consumer. (shrink)

In the Alcibiades I, Socrates argues for the importance of self-knowledge. Recent interpreters contend that the self-knowledge at issue here is knowledge of an impersonal and purely rational self. I argue against this interpretation and advance an alternative. First, the passages proponents of this interpretation cite—Socrates’ argument that the self is the soul, and his suggestion that Alcibiades seek self-knowledge by looking for his soul’s reflection in the soul of another—do not unambiguously support their reading. Moreover, other passages, particularly Socrates’ (...) cross-examination of Alcibiades, suggest the contrary reading, that self-knowledge includes knowledge of qualities peculiar to the individual. (shrink)

ABSTRACTMany texts in the Epicurean tradition mention gratitude but do not explicitly explain its function in Epicurean ethics. I review passages that mention or discuss gratitude and ingratitude a...

In this paper I hope to show that Geach misunderstands the nature of Plato's argument in the Euthyphro and more importantly the reasoning behind the dialectical strategy adopted by Socrates. Furthermore I shall argue that Geach's reading of the Euthyphro engenders serious difficulties, that stand in the way of understanding the manner in which Plato construes the problem of determining the nature of, and relationship between universal and particulars, which is of great significance because it is precisely this problem, in (...) relation to piety, that is central to the Euthyphro. In the appendix I shall sketch the outline of an argument in order to justify the assumption that the theory of Forms is present in the Euthyphro. (shrink)

Nicholas Dixon’s Kantian argument for why mixed martial arts (MMA) is intrinsically immoral has received several critical responses. We offer an additional critical response. Unlike previous responses, ours does not rely on an interpretation of the categorical imperative that Dixon would find tendentious. Instead, we grant that Dixon’s views about what makes other sports consistent with the categorical imperative are correct and argue from this assumption that MMA is also consistent with the categorical imperative. Our argument focuses on Dixon’s claims (...) about certain cycling tactics, which we call ‘pain-leveraging cycling tactics’. We argue that MMA is consistent with the categorical imperative for the same sort of reasons that Dixon claims make pain-leveraging cycling tactics consistent with the categorical imperative. (shrink)

Many attempts have been made in recent months to throw light on the problem of vagueness. That perfect precision is an ideal not to be attained by any language seems clear. But the obvious fact is that words and sentences in our languages are not so precise as we should like to have them, and we are naturally concerned with finding some sort of device by which vagueness can, in the first place, be detected and measured, and, in the second (...) place, eliminated or reduced to a minimum. I shall not be concerned in what follows with these various special attempts to meet the problem. My task is the somewhat more general one of showing that there are other factors contributing to vagueness, one of which is of particular significance when we leave the realm of ostensively defined symbols and begin to concern ourselves with suppositional symbols, constructs and hypotheses. (shrink)

In recent years, Plato’s Lysis has received much attention from professional scholars, but could it be used as a text in introductory classes? It is true that the Lysis poses challenges as an introductory text—its arguments are fast-paced and abstract. But I argue that the Lysis is actually an excellent pedagogical text, well suited to engage novices and introduce them to philosophy’s distinctive methods and way of thinking. It works particularly well as a text for engaging students in active learning, (...) insofar as it opens up a space for improvisation and exploration, providing tools for the readers and inviting them to take an active role in constructing their own understandings. (shrink)

Richard Posner, Not a Suicide Pact: The Constitution in a Time of National Emergency New York: Oxford University Press, 2006, 208 pp.

It is helpful for any enterprise to stop occasionally and examine itself. Science has done this rather infrequently in its long and eventful history, and there has not been, in general, any continuity in these self-examinations. As a result the history of the philosophy of science has been a rather spotty affair. My belief is that the philosophy of science should also, at times, become self-critical. When a study is concerned primarily with methods of other disciplines it tends to underemphasize (...) the role played by the methods which it itself uses. What is the method of the philosophy of science, and is it justifiable? Can there be a satisfactory study of science and can this be scientific? (shrink)

I suppose it is generally agreed that the task of science is to render intelligible, or in some way account for, the objects and events of our experience. Usually we say that the job of science is to explain. While this is a satisfactory formulation for most purposes, it hides a difficulty. What is meant by “explanation”? The many interpretations of this word divide scientists and philosophers of science into sharply differentiated schools. For some “explanation” means answering the question, Why?; (...) for others it means merely describing. For some it means finding causes; for others it means finding effects or abandoning entirely the search for causes and effects. For some it means employing quantitative methods only; for others it means supplementing or replacing quantitative methods by qualitative. For some it means interpreting or understanding; for others it means merely adjusting oneself in a practical way. (shrink)

There are some indications that the philosophy of science is reaching the age of discretion. Now, as I understand it, the age of discretion is characterized by self-examination. Youth is a period of blundering enthusiasm. But maturity demands the sobering influence of principles, perspectives and techniques. The adult must put away childish things. This does not demand the elimination of spontaneity and imagination, but it does require their chastening according to the principles of propriety. It seems time to ask ourselves (...) whether the philosophy of science ought to be allowed henceforth just to grow, like Topsy, or whether a serious attempt ought not to be made to determine its nature and task. (shrink)

Some recent and historical writers in the philosophy of science have concerned themselves with a certain problem which seems to occupy, at least in the minds of those who have written about it, a position of peculiar importance. Whether the problem is really as significant as its authors maintain need not be decided here; certainly many writers in this area have either neglected it or made only vague allusions to it. It can best be described as the problem of the (...) development of science, and it is usually solved in terms of a certain theory that science passes in its growth, either naturally or under the control of conscious logical techniques, through various “stages” or “phases.” For some strange reason these levels are usually exactly three in number. One would like to believe that this number is not a magic one, but empirically demanded by the actual way in which the sciences develop. But the fact that the descriptions of these stages in the writings of the various authors appear to agree only in their triplicity, and not in content, would incline one to believe otherwise. There is, in fact, the slight suspicion that the number three has been preferred to the number two simply because a triad may be ordered in a way in which a couple may not, and to the number four or any larger number merely because of the preference for simplicity over complexity. (shrink)

The term qittīer designates the act of burning the food offerings, the 'iššîm, within the ritual sequence of all three types of sacrifice, the zébach, the ōlāh, and the minchāh. Incense is not an 'iššeh substance and is never associated with this piel conjugation. Qittēr appears to have been limited to intransitive use, while the synonyms hiqtîr and heelāh were used predominantly in transitive constructions. By the exilic or post-exilic period, hiqtîr seems to have become the preferred form for intransitive (...) use as well, supplanting qittēr completely. The term has no overtones of illegitimacy, as commonly presumed. (shrink)